Adrena Sense (Lora Vanderhaeghe)
Less Stress, More Energy
What to expect from this product:
- Increase in energy, endurance and well-being
- Rejuvenation, increased sexual performance
- Enhanced immune function, and anti-tumor properties
- Reduced pain and inflammation (injuries, arthritis)
- Antioxidant properties that fight free radical damage
- Cardiovascular protection
Suggested usage: 1-3 capsules daily with meals or as directed by a health practitioner.
Each Capsule Contains:
Rhodiola rosea Extract (3.5% total rosavins) 100 mg
Rhodiola increases resistance of the body to chemical, biological and physical stressors. In Russia it has been used for centuries and has very powerful anti-aging and anti-stress activity. Rhodiola enhances mental and physical performance and is more powerful than other adaptogens (see below). Most adaptogens are warming in nature but Rhodiola is cooling and as a result is useful for menopausal women. It has been proven to enhance the immune system and to have anti-depressive and anti-tumor activity. Studies also show that Rhodiola regulates the heart by increasing oxygen utilization.
Suma (Pfaffia Paniculata) 100 mg
Suma is called "para todo" which means "for everything". It is considered a regenerative tonic for the nervous, reproductive and digestive systems and is used to treat hormonal disorders, sexual dysfunction, sterility, arteriosclerosis, fatigue, diabetes, cancer and many types of stress. Nutritionally Suma contains 19 amino acids, electrolytes and trace minerals including iron, magnesium, silicae, zinc and vitamins A, B-1, B-2, E, K and pantothenic acid.
Siberian Ginseng (Eleutherococcus senticosus)
(0.8% eleutherosides)(15:1 from 1500 mg Siberian Ginseng) 100 mg
Siberian Ginseng is not actually a ginseng but it is called one because of similar properties. It would more accurately be called by its Latin name, 'Eleuthro'. It has been shown to normalize reactions to physical and mental stress and increase the body's ability to withstand adverse conditions such as heat, noise, increases in workload and physical endurance. It promotes vital energy, reduces frequency of illness, protects against environmental pollutants, regulates blood-sugar, protects the liver, and supports optimal adrenal function.
Schizandra Berries (Schizandra chinensis)
(2% Schisandrins)(5:1 from 400 mg Schisandra) 80 mg
Schizandra is commonly used as a general tonic and to promote liver health. It counters the effects of stress and fatigue. Studies show it has normalizing effects in cases of insomnia, nervousness and improves physical endurance, mental capability and is hepato-protective. It has also been found to have antioxidant and antibacterial properties.
Ashwagandha (Withana Somnifera)
(1.5% withanolides)(5:1 from 400 mg Ashwagandha) 80 mg
Aswagandha is widely used in Ayurvedic medicine, the medical system of India. It is used primarily as a general tonic to increase energy and to improve overall health and longevity. Studies have proven the powerful anti-stress effects as well as the antioxidant and anti-inflammatory properties, anti-tumor properties as well as the immune modulating properties. Ashwagandha has been shown to improve sexual performance, have calming effects on the central nervous system, and overall rejuvenating effects.
Encapsulated in a vegetarian capsule (cellulose, purified water) with rice powder and vegetable grade magnesium stearate (Lubricant).
*All of the herbs in AdrenaSense are Adaptogens
Note from Dr. Karen Jensen
* What are Adaptogens?
Stress adaptation is the body's ability to respond to a stressor with little or no prolonged stress-hormone reaction. Adaptogenic herbs enhance the ability of the body to resist the stressors and are called the 'great equalizers'. Adaptogens exert a normalizing influence on the body, neither over-stimulating nor inhibiting normal body function, but providing a generalized tonifying effect.
"To understand the mechanism of stress gives physicians a new approach to treatment of illness but it can also give us all a new way of life, a new philosophy to guide our actions in conformity with natural laws."
Hans Selye, MD
Anticarcinogenic activity of Withania somnifera Dunal against Dalton's Ascitic Lymphoma. Uthangudi, Melur Road, Madurai 625 107, Tamil Nadu, India. J Ethnopharmacol. 2004 Aug;93(2-3):359-61. The effect of ethanolic extract of the root of Withania somnifera against Dalton's Ascitic Lymphoma has been evaluated in Swiss albino mice. A significant increase in the life span and a decrease in the cancer cell number and tumour weight were noted in the tumour-induced mice after treatment with ashwagandha. The hematological parameters were also corrected by ashwagandha in tumor-induced mice. These observations are suggestive of the protective effect of ashwagandha in Dalton's Ascitic Lymphoma.
Growth inhibition of human tumor cell lines by withanolides from Withania somnifera (ashwagandha) leaves. Jayaprakasam B. Michigan State University, East Lansing, MI 48824, USA. Life Sci. 2003 Nov 21;74(1):125-32. Ayurvedic medicines prepared in India consist of Withania somnifera roots (ashwagandha) as one of the main ingredients. Ashwagandha is consumed as a dietary supplement around the world. The leaves of ashwagandha were used in the treatment of tumors and inflammation in several Asian countries. We have isolated twelve withanolides from the leaves of this species. Compounds were tested for their anti-proliferative activity on NCI-H460 (Lung), HCT-116 (Colon), SF-268 (Central Nervous System; CNS and MCF-7 (Breast) human tumor cell lines. Withaferin A and its derivatives exhibited inhibitory concentrations (50%) ranging from 0.24 +/- 0.01 to 11.6 +/- 1.9 microg/mL. Viscosalactone B (12) showed the 50% inhibition at concentrations ranging from 0.32 +/- 0.05 to 0.47 +/- 0.15 microg/mL whereas its 27-O-glucoside derivative (10) exhibited IC50 between 7.9 +/- 2.9 and 17.3 +/- 3.9 microg/ml. Therefore, incorporation of ashwagandha in the diet may prevent or decrease the growth of tumors in human.
Withania somnifera (Ashwagandha) attenuates antioxidant defense in aged spinal cord and inhibits copper induced lipid peroxidation and protein oxidative modifications.Gupta SK. Department of Zoology, Kurukshetra University, Haryana, India. Drug Metabol Drug Interact. 2003;19(3):211-22. Ashwagandha is classified in Ayurveda, the ancient Indian system of medicine, as a rasayana, a group of plant-derived drugs which promote physical and mental health, augment resistance of the body against disease and diverse adverse environmental factors, revitalize the body in debilitated conditions and increase longevity. We investigated the effects of Ashwagandha on copper-induced lipid peroxidation and antioxidant enzymes in aging spinal cord of Wistar rats. The activity of glutathione peroxidase (GPx) decreased significantly in the spinal cord from adult to aged mice. Treatment with Ashwagandha successfully attenuated GPx activity and inhibited lipid peroxidation in a dose dependent manner. Ashwagandha inhibited both the lipid peroxidation and protein oxidative modification induced by copper. These effects were similar to those of superoxide dismutase and mannitol. The results indicate the therapeutic potential of Ashwagandha in aging and copper-induced pathophysiological conditions.
Induction of nitric oxide synthase expression by Withania somnifera in macrophages.
Iuvone T, Esposito G, Life Sci. 2003 Feb 21;72(14):1617-25.
University of Naples Federico II, via D. Montesano 49, 80131, Naples, Italy.
Withania somnifera (ashwagandha, Indian ginseng) is an immunostimulant herbal medicine used to improve overall health and prevent diseases, particularly in the elderly. However, the mechanisms underlying its immunostimulant effect is poorly understood. To elucidate the mechanism of Withania somnifera, we investigated the effect of a methanolic extract from the root of Ashwagandha on nitric oxide (NO) production in J774 macrophages. We found that WS (1-256 microg/ml) produced a significant and concentration-dependent increase in NO production, an effect which was abolished by N(G)nitro-L-arginine methyl ester (L-NAME, 3-300 microM), a non-selective inhibitor of NO synthase (NOS), dexamethasone (10 microM), an inhibitor of protein synthesis and N(alpha-p)-tosyl-L-lysine chloromethyl ketone (TLCK, 0.01-10 microM), an inhibitor of nuclear factor-kappaB (NF-kappaB) activation. Dexamethasone did not have any effect on NO production once NOS had been induced (i.e. 12 h after WS). Moreover, western blot analysis showed that Ashwagandha increased, in a concentration-dependent fashion, inducible NOS protein expression. These results demonstrate that WS may induce the synthesis of inducible NOS expression likely by acting at transcriptional level. The increased NO production by macrophages could account, at least in part, for the immunostimulant properties of Ashwagandha.
Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha. Kuboyama T.. Neuroreport. 2002 Oct 7;13(14):1715-20. Toyama Medical and Pharmaceutical University, Toyama, Japan. We previously reported that the methanol extract of Ashwagandha (roots of Dunal) induced dendrite extension in a human neuroblastoma cell line. In this study, we found that six of the 18 compounds isolated from the methanol extract enhanced neurite outgrowth in human neuroblastoma SH-SY5Y cells. Double immunostaining was performed in rat cortical neurons using antibodies to phosphorylated NF-H as an axonal marker, and to MAP2 as a dendritic marker. In withanolide A-treated cells, the length of NF-H-positive processes was significantly increased compared with vehicle-treated cells, whereas, the length of MAP2-positive processes was increased by withanosides IV and VI. These results suggest that axons are predominantly extended by withanolide A, and dendrites by withanosides IV and VI.
Hypoglycemic, diuretic and hypocholesterolemic effect of winter cherry (Withania somnifera, Dunal) root. Andallu B, Radhika B. Sri Satya Sai Institute of Higher Learning, Anantapur 515001, India. Indian J Exp Biol. 2000 Jun;38(6):607-9. Hypoglycemic, diuretic and hypocholesterolemic effects of roots of W. somnifera (ashwagandha) were assessed on human subjects. Six mild NIDDM subjects and six mild hypercholesterolemic subjects were treated with the powder of roots of ashwagandha for 30 days. Suitable parameters were studied in the blood and urine samples of the subjects along with dietary pattern before and at the end of treatment period. Decrease in blood glucose was comparable to that of an oral hypoglycemic drug. Significant increase in urine sodium, urine volume, significant decrease in serum cholesterol, triglycerides, LDL (low density lipoproteins) and VLDL (very low density lipoproteins) cholesterol were observed indicating that root of ashwagandha is a potential source of hypoglycemic, diuretic and hypocholesterolemic agents. Clinical observations revealed no adverse effects.
Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review.
Altern Med Rev. 2000 Aug;5(4):334-46. Mishra LC, Singh BB, Dagenais S.
Los Angeles College of Chiropractic (LACC), 16200 E Amber Valley Dr., Whittier, CA 90609-1166.
OBJECTIVE: The objective of this paper is to review the literature regarding Withania somnifera (ashwagandha) a commonly used herb in Ayurvedic medicine. Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity. DESIGN: This review is in a narrative format and consists of all publications relevant to ashwagandha that were identified by the authors through a systematic search of major computerized medical databases; no statistical pooling of results or evaluation of the quality of the studies was performed due to the widely different methods employed by each study. RESULTS: Studies indicate ashwagandha possesses anti-inflammatory, antitumor, antistress, antioxidant, immunomodulatory, hemopoietic, and rejuvenating properties. It also appears to exert a positive influence on the endocrine, cardiopulmonary, and central nervous systems. The mechanisms of action for these properties are not fully understood. Toxicity studies reveal that ashwagandha appears to be a safe compound. CONCLUSION: Preliminary studies have found various constituents of ashwagandha exhibit a variety of therapeutic effects with little or no associated toxicity. These results are very encouraging and indicate this herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Clinical trials using ashwagandha for a variety of conditions should also be conducted.
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